News

The Final ImResFun Scientific Conference of the EC-funded Marie-Curie Initial Training Network ImResFun is now announced.

Publication: Candidalysin is a fungal peptide toxin critical for mucosal infection

ITN Practical Course "C2a", Barcelona, Spain (May 10-15, 2015)

ITN Meeting, La Colle sur Loup, France (May 16, 2015)

HPF2015, La Colle sur Loup, France (May 16-22, 2015)

ITN Practical Course "S3" & "C3", Madrid, Spain (July 6-10, 2015)

ITN Mid-Term Review Meeting, Vienna, Austria (November 3, 2015)

ITN Practical Course "S5" & "C5", Tübingen, Germany (May 9-11, 2016)

ITN Lecture Course "S4" & "C4", Szeged, Hungary (July 2-8, 2016)

ITN Practical Course "S6" & "C6", Göttingen, Germany (October 26-28, 2016)

ITN Symposium "S7" & Final Consortium Meeting, Innsbruck, Austria (January 28-30, 2017)

 

Scientific Background

 

P1 - MUW (Vienna)
Recent years, chromatin remodeling in both fungal pathogens and the host has become an important emerging field as it is considered a key regulator of survival strategy and pathogen recognition, respectively. Hence, understanding the role of chromatin modifiers is a need of the hour. We could show that CaGcn5, a histone acetyl transferase, is required for various functions like altered antifungal drug tolerance, histone acetylation, hyphal formation, metabolism and stress signaling.


P2 - FhG (Stuttgart)

(ESR) When a fungus gets in contact with the human body, it is recognized by receptors on the cell surface, allowing the body to know about the presence of an invader and defend itself. We are looking for new substances that act on these receptors and could be used as antifungals.

(ER) Human pathogenic fungi can live on body surfaces without harming the host. However, under certain conditions this harmless relation may lose balance leading to host tissue destruction and disease. By developing and applying complex cellular models for both states of Host-pathogen interaction we aim to study this equilibrium.


P3 - SU-GU (Stockholm)
Candida albicans cells extract nutrients during growth in infected hosts. We aim to understand how C. albicans respond to the presence of amino acids, which are preferred sources of nitrogen. The role of SPS pathway is being deciphered with the goal of finding novel therapeutic agents to combat fungal infections.


P4 - UMG-GOE (Göttingen)
This project aims to better understand the C. glabrata cell wall with regard to biofilm formation, and its use of different adhesin isoforms. Furthermore we seek to use its components to develop novel species-specific  biomarkers to detect fungal disease including both, cell wall proteins as well as glycostructures of extracellular protein N- and O- glycosylation released from the fungus.


P5 - KCL (London)
The fungus Candida albicans causes many types of epithelial (oral, vaginal, gut) infections in humans. This project aims to determine how a newly discovered toxin produced by this fungus promotes infections at these body sites and whether it activates immunity and causes cell death in epithelial cells.


P6 - FGU (Prague)
Characterization of proteins transporting protons, sodium and potassium in pathogenic Candida cells and finding inhibitors of these transporters that can be used as new antifungal drugs.


P7 - EMC (Tübingen)

ESR-7 has designed and synthesized a collection of drug-like peptides and heterocycles with high potency for biological activity using robust and reproducible procedures for solid phase and solution phase synthesis. The analytical characterization of the compounds has been carried out using high-pressure liquid chromatography and mass spectrometry.


P8 - UCM (Madrid)

Invasive fungal infections often take place when a person’s natural defenses are weakened. Our group will use breakthrough proteomic approaches to study the activation of signaling pathways in immune cells invaded by Candida albicans cells and we will also identify several biomarkers for the diagnosis of these fungal infections.

P9 - USZ (Szeged)
Candida parapsilosis causes severe infections especially in young children and low birth weight newborns. We aim to investigate the pathogenesis and the host immune response induced by this emerging human fungal pathogen.


P10 - CRG (Barcelona)
The Project of ESR Ernst Thuer consists of designing and implementing approaches to deal with the complexity of modern biological data, in order to obtain biologically relevant knowledge. Modern methods , such as Next Generation Sequencing, provide an immense wealth of information, but at the cost of a so far unmatched level of complexity.


P11 - Labdia (Vienna)

Individuals with impaired immunity, such as cancer patients on chemotherapy or transplant recipients, have a high risk of life-threatening bacterial and fungal infections. The project focuses on the investigation of interactions between bacteria and fungi to provide a basis for the identification of new diagnostics targets for improved treatment strategies.


P12 - QIAGEN (Aarhus)

QIAGEN is analyzing a number of RNA-Seq data from different partners. The data go through the pipeline developed by the ESR Nitesh Kumar Singh for generating differentially expressed genes. The human differentially expressed genes are then analyzed using Ingenuity pathway analysis for functional analysis.